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1.
Synthesis and pharmacological evaluation of enantiomerically pure endo-configured KOR agonists with 2-azabicyclo[3.2.1]octane scaffold.
Org Biomol Chem
; 19(38): 8384-8396, 2021 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34528988
2.
Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure σ ligands with 2-benzopyran structure.
Bioorg Med Chem
; 25(13): 3384-3395, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28501431
3.
Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Bioorg Med Chem
; 23(15): 4277-4285, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26145819
4.
Diastereoselective Synthesis of Cyclic Five-Membered trans,trans-Configured Nitrodiols by Double Henry Reaction of 1,4-Dialdehydes.
Arch Pharm (Weinheim)
; 348(8): 589-94, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26010372
5.
Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.
Org Biomol Chem
; 12(29): 5407-26, 2014 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24934693
6.
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
J Med Chem
; 64(2): 1170-1179, 2021 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33426889
7.
Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.
J Med Chem
; 64(9): 6397-6409, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33901399
8.
Novel σ1 antagonists designed for tumor therapy: Structure - activity relationships of aminoethyl substituted cyclohexanes.
Eur J Med Chem
; 210: 112950, 2021 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33148494
9.
Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold.
J Pharm Biomed Anal
; 172: 214-222, 2019 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31060034
10.
Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.
Bioorg Med Chem
; 16(6): 2870-85, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18249546
11.
Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists.
ChemMedChem
; 13(15): 1580-1587, 2018 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29806151
12.
Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.
J Med Chem
; 50(24): 6144-53, 2007 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17967001
13.
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.
Eur J Med Chem
; 138: 552-564, 2017 Sep 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28704758
14.
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists.
J Med Chem
; 57(15): 6845-60, 2014 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25062506
15.
Design, synthesis and receptor affinity of novel conformationally restricted σ ligands based on the [4.3.3]propellane scaffold.
Eur J Med Chem
; 70: 78-87, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24140950
16.
Characterization of ligand binding to the σ(1) receptor in a human tumor cell line (RPMI 8226) and establishment of a competitive receptor binding assay.
Assay Drug Dev Technol
; 10(4): 365-74, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22192304
17.
Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.
Eur J Med Chem
; 53: 327-36, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22578786
18.
Expression of σ receptors of human urinary bladder tumor cells (RT-4 cells) and development of a competitive receptor binding assay for the determination of ligand affinity to human σ(2) receptors.
J Pharm Biomed Anal
; 55(5): 1136-41, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21550749
19.
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ1 receptor affinity.
J Med Chem
; 54(19): 6704-13, 2011 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21859078
20.
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.
J Pharm Biomed Anal
; 53(3): 603-8, 2010 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-20462722