Detalles de la búsqueda
1.
ω-(5-Phenyl-2H-tetrazol-2-yl)alkyl-substituted glycine amides and related compounds as inhibitors of the amine oxidase vascular adhesion protein-1 (VAP-1).
Bioorg Med Chem
; 98: 117558, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38142562
2.
Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure.
Bioorg Med Chem Lett
; 92: 129374, 2023 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37315699
3.
Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure.
Bioorg Med Chem
; 77: 117110, 2023 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36495814
4.
HPLC fluorescence assay for measuring the activity of diacylglycerol lipases and the action of inhibitors thereof.
Anal Biochem
; 657: 114889, 2022 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36113549
5.
ω-(5-Phenyl-2H-tetrazol-2-yl)alkyl-substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3).
Arch Pharm (Weinheim)
; 355(8): e2200111, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35507758
6.
Evaluation of inhibitors of the arachidonic acid cascade with intact platelets using an on-line dilution and on-line solid phase extraction HPLC-MS method.
Prostaglandins Other Lipid Mediat
; 155: 106551, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33940184
7.
HPLC-UV assay for the evaluation of inhibitors of plasma amine oxidase using crude bovine plasma.
J Enzyme Inhib Med Chem
; 34(1): 144-149, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30427224
8.
Non-canonical Escherichia coli transcripts lacking a Shine-Dalgarno motif have very different translational efficiencies and do not form a coherent group.
Microbiology (Reading)
; 164(4): 646-658, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29469690
9.
HPLC-UV assays for evaluation of inhibitors of mono and diamine oxidases using novel phenyltetrazolylalkanamine substrates.
Anal Biochem
; 549: 29-38, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29550344
10.
1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.
Bioorg Med Chem
; 25(3): 825-837, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27989417
11.
HPLC-UV method for evaluation of inhibitors of plasma amine oxidase using derivatization of an aliphatic aldehyde product with TRIS.
Anal Bioanal Chem
; 408(17): 4799-807, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129976
12.
Structure-activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: replacement of the activated ketone group by other serine traps.
J Enzyme Inhib Med Chem
; 31(4): 653-63, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26153239
13.
1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.
J Enzyme Inhib Med Chem
; 31(sup1): 131-140, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27162011
14.
1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase: Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability.
Bioorg Med Chem
; 23(10): 2579-92, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25862211
15.
Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones.
Biopharm Drug Dispos
; 36(6): 398-404, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25765813
16.
Convergent and enantioselective syntheses of cytosolic phospholipase A(2)α inhibiting N-(1-indazol-1-ylpropan-2-yl)carbamates.
Org Biomol Chem
; 12(23): 4021-30, 2014 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24817191
17.
1-Benzylindoles as inhibitors of cytosolic phospholipase A2α: synthesis, biological activity, aqueous solubility, and cell permeability.
RSC Med Chem
; 15(2): 641-659, 2024 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38389890
18.
Metabolism of sumatriptan revisited.
Pharmacol Res Perspect
; 11(1): e01051, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36655303
19.
HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme.
J Pharm Biomed Anal
; 229: 115354, 2023 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37003086
20.
Synthesis, activity and metabolic stability of propan-2-one substituted tetrazolylalkanoic acids as dual inhibitors of cytosolic phospholipase A2α and fatty acid amide hydrolase.
RSC Med Chem
; 14(10): 2079-2088, 2023 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37859716