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1.
Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.
Bioorg Med Chem Lett
; 26(2): 466-471, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26687487
2.
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Bioorg Med Chem Lett
; 21(12): 3627-31, 2011 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21605975
3.
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Bioorg Med Chem Lett
; 21(11): 3411-6, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21515049
4.
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Bioorg Med Chem Lett
; 21(15): 4602-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21715165
5.
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Bioorg Med Chem Lett
; 21(8): 2278-82, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21420297
6.
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Bioorg Med Chem Lett
; 19(13): 3445-8, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19464885
7.
Discovery of highly potent and selective type I B-Raf kinase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6571-4, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19854649
8.
3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Bioorg Med Chem Lett
; 19(16): 4546-50, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19625186
9.
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.
Bioorg Med Chem Lett
; 19(24): 6957-61, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19875283
10.
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Bioorg Med Chem Lett
; 19(23): 6519-23, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19864136
11.
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem
; 17(11): 3857-65, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19410464
12.
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.
Mol Cancer Ther
; 6(11): 3028-38, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17989320
13.
A rat pharmacokinetic/pharmacodynamic model for assessment of lipopolysaccharide-induced tumor necrosis factor-alpha production.
J Pharmacol Toxicol Methods
; 56(1): 67-71, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17391989
14.
Design strategies for the identification of MMP-13 and Tace inhibitors.
Curr Opin Drug Discov Devel
; 6(5): 742-59, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-14579524
15.
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
Curr Top Med Chem
; 4(12): 1289-310, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15320727
16.
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
J Med Chem
; 47(25): 6255-69, 2004 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15566296
17.
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
J Med Chem
; 46(12): 2376-96, 2003 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12773042
18.
Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity.
J Med Chem
; 53(21): 7874-8, 2010 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20961062
19.
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.
J Med Chem
; 52(8): 2181-4, 2009 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19309081
20.
Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.
Bioorg Med Chem
; 15(18): 6170-81, 2007 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17606376