Detalles de la búsqueda
1.
Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
Bioorg Chem
; 143: 107032, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38128204
2.
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities.
Drug Dev Res
; 83(6): 1292-1304, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35769019
3.
First triclosan-based macrocyclic inhibitors of InhA enzyme.
Bioorg Chem
; 95: 103498, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31855823
4.
Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA.
Bioorg Med Chem Lett
; 29(16): 2338-2344, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31227345
5.
In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA).
Molecules
; 24(14)2019 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31311157
6.
Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis.
Bioorg Chem
; 81: 440-453, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30223149
7.
Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis.
Bioorg Chem
; 75: 181-200, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28961440
8.
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity.
Molecules
; 22(9)2017 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28862683
9.
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach.
J Struct Biol
; 190(3): 328-37, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25891098
10.
Synthesis of methylerythritol phosphate analogues and their evaluation as alternate substrates for IspDF and IspE from Agrobacterium tumefaciens.
J Org Chem
; 79(19): 9170-8, 2014 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25184438
11.
In silico design, synthesis and antitubercular activity of novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones as enoyl-acyl carrier protein reductase inhibitors.
J Biomol Struct Dyn
; : 1-19, 2024 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38450660
12.
2-(9H-Fluoren-9-yl)-4-(4-fluoro-anilino)-4-oxo-butanoic acid.
Acta Crystallogr Sect E Struct Rep Online
; 69(Pt 6): o963, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23795121
13.
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur J Med Chem
; 259: 115646, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37482022
14.
A mesoporous metal-organic framework used to sustainably release copper(ii) into reducing aqueous media to promote the CuAAC click reaction.
RSC Adv
; 12(41): 26825-26833, 2022 Sep 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36320833
15.
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity.
Pharmaceuticals (Basel)
; 15(10)2022 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36297413
16.
Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.
RSC Med Chem
; 12(1): 120-128, 2021 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34046604
17.
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis.
ACS Infect Dis
; 7(3): 552-565, 2021 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33617235
18.
Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Eur J Med Chem
; 199: 112402, 2020 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32417538
19.
Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Eur J Med Chem
; 188: 112035, 2020 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31951850
20.
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors.
Eur J Med Chem
; 146: 318-343, 2018 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29407960