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1.
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
Cereb Cortex
; 31(2): 1395-1408, 2021 01 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33068001
2.
Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.
Int J Neuropsychopharmacol
; 24(6): 505-518, 2021 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33438026
3.
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.
J Pharmacol Exp Ther
; 372(1): 83-94, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31694876
4.
The Effects of pH on the Structure and Bioavailability of Imidazobenzodiazepine-3-Carboxylate MIDD0301.
Mol Pharm
; 17(4): 1182-1192, 2020 04 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32069056
5.
A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor.
Molecules
; 25(17)2020 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32854311
6.
A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo.
Am J Physiol Lung Cell Mol Physiol
; 316(2): L385-L390, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30489155
7.
Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.
J Neurooncol
; 142(3): 411-422, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30725256
8.
GABAA Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators.
Alcohol Clin Exp Res
; 43(5): 791-802, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30861153
9.
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.
Behav Pharmacol
; 30(5): 452-461, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30640180
10.
Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.
J Pharmacol Exp Ther
; 366(1): 145-157, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29720564
11.
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.
Mol Pharm
; 15(5): 1766-1777, 2018 05 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29578347
12.
Neurobiological correlates of state-dependent context fear.
Learn Mem
; 24(9): 385-391, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28814463
13.
Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.
Mol Pharm
; 14(6): 2088-2098, 2017 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28440659
14.
Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.
Mol Pharm
; 13(6): 2026-38, 2016 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27120014
15.
Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung".
Mol Pharm
; 16(11): 4756, 2019 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31633359
16.
Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2.
Antiviral Res
; 213: 105586, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36997073
17.
Machine Leaning-Based Optimization Algorithm for Myocardial Injury under High-Intensity Exercise in Track and Field Athletes.
Comput Intell Neurosci
; 2022: 7792958, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35586102
18.
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models.
J Med Chem
; 65(4): 2785-2793, 2022 02 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523654
19.
Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABAA receptors.
Behav Brain Res
; 428: 113832, 2022 06 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35259414
20.
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants.
Sci Transl Med
; 14(661): eabm7621, 2022 09 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35579533