Detalles de la búsqueda
1.
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell
; 172(3): 578-589.e17, 2018 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29373830
2.
Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.
J Biol Chem
; 288(8): 5718-31, 2013 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23275335
3.
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J Clin Invest
; 130(2): 981-997, 2020 02 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31855575
4.
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(2): 451-8, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19054673
5.
5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(21): 6047-52, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19796938
6.
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 19(22): 6404-12, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19818610
7.
Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach.
Tetrahedron Lett
; 50(24): 2933-2935, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20160897
8.
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.
Sci Transl Med
; 11(510)2019 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31534020
9.
KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition.
Clin Cancer Res
; 25(2): 796-807, 2019 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30327306
10.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Bioorg Med Chem Lett
; 18(4): 1413-8, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242088
11.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
Bioorg Med Chem Lett
; 18(4): 1419-24, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18226901
12.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Bioorg Med Chem Lett
; 18(20): 5635-9, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18796353
13.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Bioorg Med Chem Lett
; 18(11): 3421-6, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18442904
14.
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(12): 3616-21, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18487044
15.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Bioorg Med Chem Lett
; 18(11): 3446-55, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18457949
16.
4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(16): 4628-32, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18662878
17.
[Root reshaping in combination of conservative osseous resection: a modified technique for surgical crown lengthening].
Beijing Da Xue Xue Bao Yi Xue Ban
; 40(1): 83-7, 2008 Feb 18.
Artículo
en Zh
| MEDLINE | ID: mdl-18278147
18.
The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors.
Nat Struct Mol Biol
; 25(6): 454-462, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29760531
19.
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism.
Science
; 351(6273): 604-8, 2016 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26841430
20.
Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
J Cardiovasc Pharmacol Ther
; 21(6): 536-548, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26911182