Detalles de la búsqueda
1.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
2.
Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.
Invest New Drugs
; 38(3): 765-775, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31250355
3.
Evaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor.
Xenobiotica
; 50(9): 1032-1042, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32129697
4.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30622164
5.
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Xenobiotica
; 49(7): 852-862, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30132394
6.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
7.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos
; 46(7): 943-952, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695616
8.
Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP).
Xenobiotica
; 48(5): 467-477, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28485193
9.
Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.
Xenobiotica
; 48(11): 1173-1183, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29098941
10.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos
; 44(11): 1752-1758, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543206
11.
Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.
Bioorg Med Chem Lett
; 26(2): 551-555, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26642765
12.
Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.
J Biol Chem
; 286(5): 3815-28, 2011 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-21107009
13.
Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination.
J Biol Chem
; 286(11): 9443-56, 2011 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21209460
14.
The Multi-Kinase Inhibitor Lucitanib Enhances the Antitumor Activity of Coinhibitory and Costimulatory Immune Pathway Modulators in Syngeneic Models.
J Immunother
; 45(8): 335-348, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35791438
15.
Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer.
Eur J Drug Metab Pharmacokinet
; 47(5): 711-723, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35844029
16.
Clinical Pharmacokinetics and Pharmacodynamics of Rucaparib.
Clin Pharmacokinet
; 61(11): 1477-1493, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36107395
17.
A phase 1, open-label, drug-drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 88(5): 887-897, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34370076
18.
Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment.
Cancer Chemother Pharmacol
; 88(2): 259-270, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33909097
19.
Inhibition of hepatic organic anion-transporting polypeptide by RNA interference in sandwich-cultured human hepatocytes: an in vitro model to assess transporter-mediated drug-drug interactions.
Drug Metab Dispos
; 38(9): 1612-22, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20516252
20.
Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A.
Clin Pharmacol Ther
; 106(5): 1056-1066, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31102467