Detalles de la búsqueda
1.
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.
Bioorg Med Chem
; 78: 117130, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36542958
2.
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat.
Drug Metab Dispos
; 49(1): 53-61, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33148688
3.
Increasing Complexity: A Practical Synthetic Approach to Three-Dimensional, Cyclic Sulfoximines and First Insights into Their in Vitro Properties.
Chemistry
; 26(19): 4378-4388, 2020 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31961028
4.
Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma.
Blood
; 130(9): 1114-1124, 2017 08 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28646117
5.
Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes.
Drug Metab Dispos
; 47(1): 49-57, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30409837
6.
Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N-Functionalized Tertiary Sulfonimidamides.
Chemistry
; 24(37): 9295-9304, 2018 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29726583
7.
Pharmacokinetics in Drug Discovery: An Exposure-Centred Approach to Optimising and Predicting Drug Efficacy and Safety.
Handb Exp Pharmacol
; 232: 235-60, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26330260
8.
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Cell Chem Biol
; 2024 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38537632
9.
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21.
J Med Chem
; 66(5): 3431-3447, 2023 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36802665
10.
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069.
J Med Chem
; 65(21): 14843-14863, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36270630
11.
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
Cell Oncol (Dordr)
; 44(3): 581-594, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33492659
12.
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
J Med Chem
; 64(15): 11651-11674, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34264057
13.
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
J Med Chem
; 64(21): 15883-15911, 2021 11 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34699202
14.
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
J Med Chem
; 64(17): 12723-12737, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34428039
15.
Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.
J Med Chem
; 63(21): 12574-12594, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33108181
16.
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
J Med Chem
; 63(13): 7293-7325, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32502336
17.
The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Mol Cancer Ther
; 19(1): 26-38, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31582533
18.
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J Med Chem
; 63(15): 8025-8042, 2020 08 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32338514
19.
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.
Neuro Oncol
; 11(2): 158-66, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18780814
20.
Quantitative molecular tissue atlas of Bis(monoacylglycero)phosphate and phosphatidylglycerol membrane lipids in rodent organs generated by methylation assisted high resolution mass spectrometry.
Anal Chim Acta
; 1084: 60-70, 2019 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31519235