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1.
Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study.
J Clin Psychopharmacol
; 43(2): 113-121, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36700734
2.
Low-dose empagliflozin as adjunct-to-insulin therapy in type 1 diabetes: A valid modelling and simulation analysis to confirm efficacy.
Diabetes Obes Metab
; 22(3): 427-433, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31858718
3.
Population pharmacokinetics of adalimumab biosimilar adalimumab-adbm and reference product in healthy subjects and patients with rheumatoid arthritis to assess pharmacokinetic similarity.
Br J Clin Pharmacol
; 86(11): 2274-2285, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32363771
4.
Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
Eur J Drug Metab Pharmacokinet
; 47(1): 91-103, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34716565
5.
Switching Between Adalimumab Reference Product and BI 695501 in Patients with Chronic Plaque Psoriasis (VOLTAIRE-X): A Randomized Controlled Trial.
Am J Clin Dermatol
; 23(5): 719-728, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35934770
6.
A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes.
Pharmaceutics
; 13(4)2021 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33918261
7.
Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder.
Br J Clin Pharmacol
; 70(1): 88-101, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20642551
8.
Population pharmacokinetics of nintedanib, an inhibitor of tyrosine kinases, in patients with non-small cell lung cancer or idiopathic pulmonary fibrosis.
Cancer Chemother Pharmacol
; 81(1): 89-101, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29119292
9.
Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study.
Eur J Drug Metab Pharmacokinet
; 43(2): 239-249, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29076028
10.
Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics.
Clin Drug Investig
; 38(8): 737-750, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29846887
11.
Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.
Clin Transl Sci
; 11(6): 616-623, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30136756
12.
Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery.
J Clin Pharmacol
; 47(3): 371-82, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17322149
13.
Enhanced elimination of dabigatran: Identifying the appropriate patient for the use of continuous venovenous hemodialysis instead of intermittent hemodialysis-A simulation analysis.
J Clin Pharmacol
; 56(5): 597-608, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26272714
14.
Dabigatran treatment simulation in patients undergoing maintenance haemodialysis.
Thromb Haemost
; 115(3): 562-9, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26467062
15.
Pharmacometric characterization of dabigatran hemodialysis.
Clin Pharmacokinet
; 52(6): 453-62, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23529813
16.
Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease.
Thromb Haemost
; 109(4): 596-605, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23389759
17.
Dabigatran etexilate in atrial fibrillation patients with severe renal impairment: dose identification using pharmacokinetic modeling and simulation.
J Clin Pharmacol
; 52(9): 1373-8, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21956604
18.
Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity.
Thromb Haemost
; 103(6): 1116-27, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20352166
19.
Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.
Br J Clin Pharmacol
; 62(5): 527-37, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17061960
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