Detalles de la búsqueda
1.
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
Acc Chem Res
; 56(12): 1395-1405, 2023 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37071750
2.
Rational design of a conformation-specific antibody for the quantification of Aß oligomers.
Proc Natl Acad Sci U S A
; 117(24): 13509-13518, 2020 06 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32493749
3.
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
Nat Prod Rep
; 39(4): 742-753, 2022 04 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34698757
4.
Systematic development of small molecules to inhibit specific microscopic steps of Aß42 aggregation in Alzheimer's disease.
Proc Natl Acad Sci U S A
; 114(2): E200-E208, 2017 01 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28011763
5.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proc Natl Acad Sci U S A
; 114(6): E1009-E1017, 2017 02 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28096355
6.
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers.
Int J Mol Sci
; 21(22)2020 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33212787
7.
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-ß Oligomers.
Int J Mol Sci
; 21(12)2020 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32630615
8.
Localized drug application and sub-second voltammetric dopamine release measurements in a brain slice perfusion device.
Anal Chem
; 86(9): 4151-6, 2014 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24734992
9.
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.
Mol Neurodegener
; 19(1): 20, 2024 Feb 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38378578
10.
A Relationship between the Structures and Neurotoxic Effects of Aß Oligomers Stabilized by Different Metal Ions.
ACS Chem Neurosci
; 15(6): 1125-1134, 2024 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38416693
11.
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-ß Aggregation.
ACS Chem Neurosci
; 14(4): 657-666, 2023 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36728544
12.
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity.
Chem Biol Interact
; 371: 110307, 2023 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36535315
13.
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes.
J Med Chem
; 66(14): 9519-9536, 2023 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37433124
14.
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents.
ACS Chem Neurosci
; 13(8): 1219-1231, 2022 04 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35404569
15.
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
Commun Biol
; 4(1): 843, 2021 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34234268
16.
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-ß and α-Synuclein and Suppress the Toxicity of Their Oligomers.
Front Neurosci
; 15: 680026, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34220435
17.
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Front Cell Dev Biol
; 9: 552549, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33829010
18.
Non-Pharmaceutical Interventions and Military Hygiene at the United States Military Academy between 1890 and 1910.
Mil Med
; 185(11-12): e2104-e2109, 2020 12 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32870979
19.
A rationally designed bicyclic peptide remodels Aß42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
Sci Rep
; 10(1): 15280, 2020 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32943652
20.
Small-molecule sequestration of amyloid-ß as a drug discovery strategy for Alzheimer's disease.
Sci Adv
; 6(45)2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33148639