Detalles de la búsqueda
1.
Development of biotinylated and magnetic bead-immobilized enzymes for efficient glyco-engineering and isolation of antibodies.
Bioorg Chem
; 112: 104863, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33823405
2.
Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.
J Am Chem Soc
; 140(15): 5202-5210, 2018 04 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29578688
3.
A common glycan structure on immunoglobulin G for enhancement of effector functions.
Proc Natl Acad Sci U S A
; 112(34): 10611-6, 2015 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26253764
4.
Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.
Bioorg Med Chem Lett
; 18(7): 2311-5, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18358720
5.
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.
Bioorg Med Chem Lett
; 18(19): 5206-8, 2008 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18790640
6.
Correction: Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies.
Chem Commun (Camb)
; 54(56): 7858, 2018 07 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29966030
7.
Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies.
Chem Commun (Camb)
; 54(48): 6161-6164, 2018 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29809215
8.
Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.
J Med Chem
; 50(7): 1514-27, 2007 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17352464
9.
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
J Med Chem
; 50(17): 4162-76, 2007 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17658776
10.
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.
Bioorg Med Chem Lett
; 17(23): 6593-601, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17935989
11.
Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors.
Bioorg Med Chem Lett
; 17(23): 6499-504, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17931867
12.
An Effective Bacterial Fucosidase for Glycoprotein Remodeling.
ACS Chem Biol
; 12(1): 63-72, 2017 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28103685
13.
Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.
Clin Cancer Res
; 11(8): 3045-54, 2005 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15837760
14.
Phenyl Glycolipids with Different Glycosyl Groups Exhibit Marked Differences in Murine and Human iNKT Cell Activation.
ACS Chem Biol
; 11(12): 3431-3441, 2016 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27782396
15.
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
J Med Chem
; 48(9): 3118-21, 2005 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15857116
16.
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
J Med Chem
; 47(3): 612-26, 2004 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-14736242
17.
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
J Med Chem
; 52(21): 6621-36, 2009 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19842661
18.
Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors.
Biomarkers
; 13(6): 579-96, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18671143
19.
Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.
Bioorg Med Chem Lett
; 17(15): 4308-15, 2007 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17544271
20.
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg Med Chem
; 15(7): 2759-67, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17287122