Detalles de la búsqueda
1.
Design, synthesis, and biological evaluation of novel bivalent PI3K inhibitors for the potential treatment of cancer.
Bioorg Chem
; 140: 106814, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37657197
2.
Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma.
Bioorg Med Chem Lett
; 71: 128825, 2022 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35644299
3.
Discovery of a novel photoswitchable PI3K inhibitor toward optically-controlled anticancer activity.
Bioorg Med Chem
; 72: 116975, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36049360
4.
Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors.
Bioorg Med Chem
; 29: 115890, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33285407
5.
Identification of Novel Thiazolo[5,4-b]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors.
Molecules
; 25(20)2020 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33053730
6.
Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3-kinase inhibitors.
Bioorg Med Chem
; 26(3): 637-646, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29305298
7.
Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.
Bioorg Med Chem Lett
; 24(18): 4538-4541, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139570
8.
Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 24(3): 790-3, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24433860
9.
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Eur J Med Chem
; 264: 116015, 2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38048697
10.
Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment.
J Med Chem
; 67(5): 3504-3519, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38377311
11.
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release.
ACS Med Chem Lett
; 14(8): 1100-1107, 2023 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37583818
12.
S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer.
Pharmaceuticals (Basel)
; 16(5)2023 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242532
13.
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.
J Med Chem
; 65(11): 8011-8028, 2022 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35609190
14.
A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models.
Acta Pharm Sin B
; 12(2): 774-786, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35256946
15.
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
J Med Chem
; 65(24): 16372-16391, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36511661
16.
Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ).
Bioorg Med Chem Lett
; 21(3): 940-3, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21216141
17.
The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway.
Front Pharmacol
; 12: 749242, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34899305
18.
Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment.
J Med Chem
; 64(11): 7331-7340, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33876637
19.
A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
Cancer Lett
; 495: 22-32, 2020 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32931884
20.
Switching the site-selectivity of C-H activation in aryl sulfonamides containing strongly coordinating N-heterocycles.
Chem Sci
; 10(38): 8744-8751, 2019 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31762973