Detalles de la búsqueda
1.
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Bioorg Chem
; 98: 103689, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32171993
2.
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proc Natl Acad Sci U S A
; 110(19): E1779-87, 2013 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23610398
3.
Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.
J Comput Aided Mol Des
; 29(1): 89-100, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25344840
4.
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem
; 21(11): 2856-67, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23618709
5.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem Lett
; 22(14): 4654-9, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22726931
6.
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem
; 19(14): 4173-82, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21708468
7.
Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus.
J Nat Prod
; 74(4): 580-4, 2011 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-21391660
8.
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
J Med Chem
; 64(19): 14477-14497, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34606263
9.
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Eur J Med Chem
; 224: 113673, 2021 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34303872
10.
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
J Med Chem
; 64(11): 7312-7330, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34009981
11.
SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes.
BMC Med Genet
; 11: 126, 2010 Aug 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20735855
12.
Repurposing old drugs as antiviral agents for coronaviruses.
Biomed J
; 43(4): 368-374, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32563698
13.
Artificial intelligence approach fighting COVID-19 with repurposing drugs.
Biomed J
; 43(4): 355-362, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32426387
14.
Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.
J Med Chem
; 62(8): 3940-3957, 2019 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30968693
15.
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 62(22): 10108-10123, 2019 11 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31560541
16.
Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
J Med Chem
; 62(24): 11135-11150, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31721578
17.
A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.
Anal Biochem
; 377(1): 89-94, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18358823
18.
Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold.
Bioorg Med Chem Lett
; 18(5): 1623-7, 2008 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18243698
19.
Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition.
Eur J Med Chem
; 151: 533-545, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29656197
20.
Antiviral drug discovery against SARS-CoV.
Curr Med Chem
; 13(17): 2003-20, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16842194