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1.
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.
Pharmacol Res
; 62(4): 337-43, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20554040
2.
Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.
J Med Chem
; 56(24): 9920-33, 2013 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24224693
3.
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.
J Med Chem
; 52(14): 4496-510, 2009 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-19530697
4.
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.
J Med Chem
; 51(17): 5397-412, 2008 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-18712856
5.
Cocaine-but not methamphetamine-associated memory requires de novo protein synthesis.
Neurobiol Learn Mem
; 87(1): 93-100, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16905344
6.
Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist.
ChemMedChem
; 5(9): 1439-43, 2010 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-20652930
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