Detalles de la búsqueda
1.
Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study.
Thromb J
; 16: 32, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30534008
2.
A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.
J Pharmacokinet Pharmacodyn
; 45(2): 235-257, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29234936
3.
Modeling and Simulation of In Vivo Drug Effects.
Handb Exp Pharmacol
; 232: 313-29, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26578524
4.
Integrating cellular metabolism into a multiscale whole-body model.
PLoS Comput Biol
; 8(10): e1002750, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23133351
5.
Multiscale mechanistic modeling in pharmaceutical research and development.
Adv Exp Med Biol
; 736: 543-61, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22161351
6.
Data-driven identification of heart failure disease states and progression pathways using electronic health records.
Sci Rep
; 12(1): 17871, 2022 10 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36284167
7.
Model-informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease.
CPT Pharmacometrics Syst Pharmacol
; 11(8): 1111-1121, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665486
8.
CKD subpopulations defined by risk-factors: A longitudinal analysis of electronic health records.
CPT Pharmacometrics Syst Pharmacol
; 10(11): 1343-1356, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34510793
9.
A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.
CPT Pharmacometrics Syst Pharmacol
; 10(6): 633-644, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33946131
10.
NT-proBNP Qualifies as a Surrogate for Clinical End Points in Heart Failure.
Clin Pharmacol Ther
; 110(2): 498-507, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33630302
11.
Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1195-1207, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34292671
12.
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
CPT Pharmacometrics Syst Pharmacol
; 10(7): 782-793, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34053199
13.
Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.
J Clin Pharmacol
; 61 Suppl 1: S70-S82, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34185905
14.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Clin Pharmacol Ther
; 109(3): 605-618, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32686076
15.
Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data.
Sci Rep
; 10(1): 21340, 2020 12 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33288774
16.
Population Pharmacokinetic and Exposure-Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease.
Clin Pharmacokinet
; 59(3): 359-370, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31583611
17.
Predictive Pediatric Modeling and Simulation Using Ontogeny Information.
J Clin Pharmacol
; 59 Suppl 1: S95-S103, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31502689
18.
Application of Physiologically-Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin.
CPT Pharmacometrics Syst Pharmacol
; 8(9): 654-663, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31310051
19.
Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach.
PLoS One
; 14(2): e0209587, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30759154
20.
Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate.
CPT Pharmacometrics Syst Pharmacol
; 7(11): 706-708, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30260082