Detalles de la búsqueda
1.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779864
2.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509903
3.
Metabolism and excretion of (S)-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies.
Xenobiotica
; 49(12): 1447-1457, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30747552
4.
Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Drug Metab Dispos
; 45(4): 409-417, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28179375
5.
Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes.
Drug Metab Dispos
; 45(5): 576-580, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28258068
6.
Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment.
Drug Metab Dispos
; 43(2): 190-8, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25384899
7.
Glatiramer acetate-induced lobular panniculitis and skin necrosis.
Cutis
; 95(3): E26-30, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25844792
8.
Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.
Drug Metab Dispos
; 42(10): 1599-610, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25024402
9.
Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.
Drug Metab Dispos
; 42(11): 1926-39, 2014 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25142735
10.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24418771
11.
The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies.
Toxicol Pathol
; 42(4): 696-708, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24771080
12.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24239482
13.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23562063
14.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23831135
15.
Remission of severe aphthous stomatitis of celiac disease with etanercept.
Clin Mol Allergy
; 11(1): 6, 2013 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24365222
16.
Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion.
Drug Metab Dispos
; 40(8): 1527-37, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22580868
17.
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.
Pharm Res
; 29(10): 2860-73, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22638872
18.
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett
; 22(1): 415-20, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22119466
19.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23089526
20.
Effect of a Ketohexokinase Inhibitor (PF-06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug.
Clin Pharmacol Ther
; 112(3): 605-614, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35355249