Detalles de la búsqueda
1.
Targeting CDK4 and 6 in Cancer Therapy: Emerging Preclinical Insights Related to Abemaciclib.
Oncologist
; 27(10): 811-821, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35917168
2.
Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells.
J Biol Chem
; 290(25): 15799-15811, 2015 Jun 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-25969534
3.
Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.
Am J Obstet Gynecol
; 212(4): 479.e1-479.e10, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25446664
4.
Overall Survival and Exploratory Biomarker Analyses of Abemaciclib plus Trastuzumab with or without Fulvestrant versus Trastuzumab plus Chemotherapy in HR+, HER2+ Metastatic Breast Cancer Patients.
Clin Cancer Res
; 30(1): 39-49, 2024 01 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37906649
5.
Clinical and Genomic Characteristics of Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors.
Clin Cancer Res
; 29(17): 3372-3383, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37289194
6.
Landscape of baseline and acquired genomic alterations in circulating tumor DNA with abemaciclib alone or with endocrine therapy in advanced breast cancer.
Clin Cancer Res
; 2023 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37889120
7.
Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant.
Clin Cancer Res
; 28(8): 1500-1506, 2022 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35121623
8.
Abemaciclib in Combination With Endocrine Therapy for Patients With Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: A Phase 1b Study.
Front Oncol
; 11: 810023, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35223458
9.
Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.
Clin Cancer Res
; 27(17): 4870-4882, 2021 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33536276
10.
Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells.
Oncotarget
; 11(17): 1478-1492, 2020 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32391118
11.
The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor-Positive Metastatic Breast Cancer.
Cancer Discov
; 10(8): 1174-1193, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32404308
12.
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Cell Rep
; 29(12): 4086-4098.e6, 2019 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31851935
13.
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.
Cell Rep
; 22(11): 2978-2994, 2018 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29539425
14.
Correction: Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant.
Clin Cancer Res
; 28(20): 4587, 2022 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36239018
15.
Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.
Cancer Cell
; 32(6): 761-776.e6, 2017 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29232554
16.
Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Cell Metab
; 24(5): 728-739, 2016 11 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27746051
17.
Correction: Activation of the IFN Signaling Pathway is Associated with Resistance to CDK4/6 Inhibitors and Immune Checkpoint Activation in ER-Positive Breast Cancer.
Clin Cancer Res
; 27(17): 4939, 2021 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34470810
18.
Molecular pathways: trafficking of metabolic resources in the tumor microenvironment.
Clin Cancer Res
; 21(4): 680-6, 2015 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25691772
19.
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Oncotarget
; 6(27): 23548-60, 2015 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26172303
20.
COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells.
Mol Cell Endocrinol
; 382(1): 358-367, 2014 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24141032