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1.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32345620
2.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Cancer Discov
; 12(6): 1482-1499, 2022 06 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35254416
3.
Efficacy of Novel Bromodomain and Extraterminal Inhibitors in Combination with Chemotherapy for Castration-Resistant Prostate Cancer.
Eur Urol Oncol
; 4(3): 437-446, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31402217
4.
BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia.
Clin Cancer Res
; 27(2): 598-607, 2021 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33148670
5.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34269576
6.
INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
PLoS One
; 15(4): e0231877, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32315352
7.
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors.
Sci Transl Med
; 12(534)2020 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32161105
8.
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.
Clin Cancer Res
; 25(1): 300-311, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30206163
9.
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
Bioorg Med Chem Lett
; 18(1): 66-71, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18037290
10.
High-throughput determination of mode of inhibition in lead identification and optimization.
J Biomol Screen
; 12(2): 220-8, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17351185
11.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16627989
12.
Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
J Med Chem
; 49(13): 3774-89, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789735
13.
Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo.
J Steroid Biochem Mol Biol
; 85(1): 71-9, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12798359
14.
Validation of standards for quantitative assessment of JAK2 c.1849G>T (p.V617F) allele burden analysis in clinical samples.
Genet Test Mol Biomarkers
; 17(5): 429-37, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23537216
15.
Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.
PLoS One
; 6(1): e15976, 2011 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-21253609
16.
Combined inhibition of Janus kinase 1/2 for the treatment of JAK2V617F-driven neoplasms: selective effects on mutant cells and improvements in measures of disease severity.
Clin Cancer Res
; 15(22): 6891-900, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19887489
17.
Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors.
Bioorg Med Chem Lett
; 17(3): 736-40, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17097290
18.
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.
Bioorg Med Chem
; 14(17): 5833-49, 2006 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16769216
19.
Correlation between the high expression of C/EBPbeta protein in F442A cells and their relative resistance to antiadipogenic action of TCDD in comparison to 3T3-L1 cells.
J Biochem Mol Toxicol
; 16(2): 70-83, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-11979424
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