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1.
Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes.
Xenobiotica
; 49(2): 177-186, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29405805
2.
The effect of fluconazole on oral methadone in dogs.
Vet Anaesth Analg
; 46(4): 501-509, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30982709
3.
A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.
Anal Chem
; 90(10): 5989-5994, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29688004
4.
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
Bioorg Med Chem Lett
; 26(19): 4637-4640, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27575469
5.
Subcutaneous meloxicam suspension pharmacokinetics in mice and dose considerations for postoperative analgesia.
J Vet Pharmacol Ther
; 39(4): 356-62, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26896236
6.
VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.
J Infect Dis
; 212(9): 1439-48, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25883390
7.
A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.
Drug Metab Dispos
; 43(11): 1718-26, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26265743
8.
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility.
Bioorg Med Chem Lett
; 25(13): 2720-5, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25987377
9.
Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.
Bioorg Med Chem Lett
; 25(8): 1757-1760, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25801932
10.
Characterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver.
Xenobiotica
; 45(6): 495-502, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25539458
11.
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.
Bioorg Med Chem Lett
; 24(19): 4708-4713, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25176330
12.
Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs.
Drug Metab Dispos
; 39(5): 789-95, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21321059
13.
Multiple-dose pharmacokinetics and opioid effects of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.
Am J Vet Res
; 82(3): 171-180, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33629900
14.
Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs.
Drug Metab Dispos
; 38(3): 396-404, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20007294
15.
Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.
Am J Vet Res
; 81(8): 656-664, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32700999
16.
Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.
Mol Cancer Ther
; 19(12): 2502-2515, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33082276
17.
CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis.
Drug Metab Dispos
; 37(8): 1682-9, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19448135
18.
Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase.
Drug Metab Dispos
; 37(3): 457-61, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19074522
19.
Novel Pure αVß3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations.
ACS Pharmacol Transl Sci
; 2(6): 387-401, 2019 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32259072
20.
In vitro drug-drug interaction screens for canine veterinary medicines: evaluation of cytochrome P450 reversible inhibition.
Drug Metab Dispos
; 36(8): 1512-8, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18448570