Detalles de la búsqueda
1.
Untargeted Metabolomics Approach for the Discovery of Environment-Related Pyran-2-ones Chemodiversity in a Marine-Sourced Penicillium restrictum.
Mar Drugs
; 19(7)2021 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34210084
2.
Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives.
Int J Mol Sci
; 22(15)2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34360530
3.
New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation.
Molecules
; 26(4)2021 Feb 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33562106
4.
Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases.
Molecules
; 26(21)2021 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34770981
5.
Precise genome editing using a CRISPR-Cas9 method highlights the role of CoERG11 amino acid substitutions in azole resistance in Candida orthopsilosis.
J Antimicrob Chemother
; 74(8): 2230-2238, 2019 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31106355
6.
4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters.
Lipids Health Dis
; 18(1): 168, 2019 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31477154
7.
The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance.
Med Mycol
; 54(7): 764-775, 2016 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27143634
8.
Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.
Bioorg Med Chem Lett
; 24(21): 5037-40, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25248682
9.
Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.
Bioorg Med Chem Lett
; 24(16): 3748-52, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25022204
10.
Study of N1-alkylation of indoles from the reaction of 2(or 3)-aminoindole-3-(or 2)carbonitriles with DMF-dialkylacetals.
Org Biomol Chem
; 10(25): 4916-25, 2012 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22618492
11.
Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.
J Enzyme Inhib Med Chem
; 26(2): 261-9, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20695753
12.
Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools.
Drug Discov Today
; 26(1): 56-68, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33137483
13.
New azole antifungals with a fused triazinone scaffold.
Eur J Med Chem
; 189: 112082, 2020 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32000050
14.
Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.
Bioorg Med Chem Lett
; 19(2): 301-4, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19091558
15.
Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.
Bioorg Med Chem Lett
; 19(20): 5833-6, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19762235
16.
Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.
J Enzyme Inhib Med Chem
; 24(5): 1067-75, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19555181
17.
Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.
Bioorg Med Chem Lett
; 18(6): 1820-4, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313295
18.
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorg Med Chem
; 16(9): 4932-53, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18439832
19.
Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.
Eur J Med Chem
; 43(7): 1469-77, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17981370
20.
Homology modeling of MT1 and MT2 receptors.
Eur J Med Chem
; 43(9): 1926-44, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18255198