Detalles de la búsqueda
1.
Design, synthesis, and biological evaluation of novel 2,3-Di-O-Aryl/Alkyl sulfonate derivatives of l-ascorbic acid: Efficient access to novel anticancer agents via in vitro screening, tubulin polymerization inhibition, molecular docking study and ADME predictions.
Bioorg Chem
; 147: 107402, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38688199
2.
Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer's disease.
Mol Divers
; 2024 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-38683486
3.
GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics.
Mol Divers
; 2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37266849
4.
Design, synthesis, and pharmacological evaluation of [1, 3] dioxolo-chromeno[2,3-b]pyridines as anti-seizure agents.
Mol Divers
; 27(4): 1809-1827, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-36214960
5.
Explorations of novel pyridine-pyrimidine hybrid phosphonate derivatives as aurora kinase inhibitors.
Bioorg Med Chem Lett
; 67: 128747, 2022 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35476959
6.
One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors.
Bioorg Med Chem Lett
; 40: 127916, 2021 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33689875
7.
Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions.
Bioorg Chem
; 115: 105174, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34314913
8.
N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition.
Mol Divers
; 25(2): 937-948, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-32249379
9.
Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization.
Bioorg Med Chem Lett
; 30(22): 127592, 2020 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33010448
10.
Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition.
Bioorg Med Chem Lett
; 30(14): 127246, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32527548
11.
Structure-Based Site of Metabolism (SOM) Prediction of Ligand for CYP3A4 Enzyme: Comparison of Glide XP and Induced Fit Docking (IFD).
Molecules
; 25(7)2020 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32244772
12.
New amide linked dimeric 1,2,3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors.
Bioorg Med Chem Lett
; 29(19): 126618, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31431361
13.
Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives.
Molecules
; 22(6)2017 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28617341
14.
Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents.
Molecules
; 21(8)2016 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27483213
15.
Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors.
Bioorg Med Chem
; 23(15): 4533-4543, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26122769
16.
Exploring the therapeutic potential of SGLT2 inhibitors in cancer treatment: integrating in silico and in vitro investigations.
Naunyn Schmiedebergs Arch Pharmacol
; 2024 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38416196
17.
Targeting Allosteric Site of PCSK9 Enzyme for the Identification of Small Molecule Inhibitors: An In Silico Drug Repurposing Study.
Biomedicines
; 12(2)2024 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38397888
18.
In silico approach towards polyphenols as targeting glucosamine-6-phosphate synthase for Candida albicans.
J Biomol Struct Dyn
; 41(21): 12038-12054, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36629053
19.
Molecular dynamic simulations based discovery and development of thiazolidin-4-one derivatives as EGFR inhibitors targeting resistance in non-small cell lung cancer (NSCLC).
J Biomol Struct Dyn
; 41(10): 4696-4710, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35532095
20.
Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions.
Eur J Med Chem
; 245(Pt 1): 114889, 2023 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36375337