Detalles de la búsqueda
1.
A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds.
Bioorg Chem
; 146: 107249, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38493638
2.
Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study.
Molecules
; 27(12)2022 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35744791
3.
Structure-activity relationships of strigolactones via a novel, quantitative in planta bioassay.
J Exp Bot
; 69(9): 2333-2343, 2018 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29554337
4.
Fragmentation pathways arising from protonation at different sites in aminoalkyl-substituted 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans).
Rapid Commun Mass Spectrom
; 32(16): 1403-1413, 2018 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-29756659
5.
Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans.
Eur J Mass Spectrom (Chichester)
; 30(1): 38-46, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37974410
6.
Tandem mass spectrometry of homologous 3-hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes.
J Mass Spectrom
; 59(6): e5043, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38789127
7.
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.
Acta Crystallogr D Struct Biol
; 80(Pt 6): 386-396, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38805244
8.
Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.
FEBS Lett
; 597(16): 2119-2132, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37278160
9.
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication.
Antiviral Res
; 219: 105734, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37852322
10.
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis.
Biomolecules
; 13(9)2023 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37759751
11.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
J Med Chem
; 65(19): 12701-12724, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36162075
12.
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication.
Antiviral Res
; 189: 105057, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33716051
13.
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats.
Brain Sci
; 12(1)2021 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35053779
14.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety.
J Med Chem
; 64(9): 5404-5428, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33844533
15.
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Bioorg Med Chem
; 18(7): 2428-38, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20299227
16.
Computational Method for Structure-Based Analysis of SAR Transfer.
J Med Chem
; 63(3): 1388-1396, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31939664
17.
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Eur J Med Chem
; 183: 111681, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557612
18.
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity.
Medchemcomm
; 10(8): 1476-1480, 2019 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31673310
19.
Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.
J Med Chem
; 62(12): 5797-5809, 2019 06 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31117514
20.
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.
ACS Med Chem Lett
; 10(4): 437-443, 2019 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30996776