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1.
Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure.
Front Immunol
; 15: 1406353, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38881900
2.
Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals.
MAbs
; 16(1): 2324801, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38441119
3.
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
J Neurosci
; 32(32): 11109-19, 2012 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22875942
4.
Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening.
J Biol Chem
; 287(40): 33691-705, 2012 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-22843695
5.
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Nat Chem Biol
; 7(12): 925-34, 2011 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22037470
6.
When to Extend Monitoring of Anti-drug Antibodies for High-risk Biotherapeutics in Clinical Trials: an Opinion from the European Immunogenicity Platform.
AAPS J
; 24(3): 68, 2022 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35554731
7.
Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice.
MAbs
; 14(1): 2143009, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36394299
8.
2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccine Assays; Immunogenicity of Biotherapeutics and Novel Modalities; Integrated Summary of Immunogenicity Harmonization).
Bioanalysis
; 14(11): 737-793, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35578991
9.
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
J Biol Chem
; 285(19): 14777-90, 2010 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-20220138
10.
Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.
J Biol Chem
; 285(49): 38183-93, 2010 Dec 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-20864533
11.
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
J Neurosci
; 29(28): 9104-14, 2009 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19605647
12.
European Immunogenicity Platform 11th Open Scientific Symposium on immunogenicity of biopharmaceuticals.
Bioanalysis
; 12(15): 1043-1048, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32803994
13.
The role of amyloidogenic protein oligomerization in neurodegenerative disease.
J Mol Med (Berl)
; 91(6): 653-64, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23529761
14.
Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples.
Methods Mol Biol
; 1017: 163-71, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23719915
15.
Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases.
Neurotherapeutics
; 10(3): 416-28, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23536253
16.
Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.
J Huntingtons Dis
; 1(1): 119-32, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-24086178
17.
TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.
Chem Biol
; 19(2): 264-75, 2012 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22365609
18.
Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.
PLoS One
; 7(9): e44457, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22984513
19.
Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.
Chem Biol
; 18(9): 1113-25, 2011 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21944750
20.
Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.
J Biol Chem
; 284(32): 21647-58, 2009 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-19491400