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1.
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
J Med Chem
; 51(1): 31-45, 2008 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18072721
2.
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Bioorg Med Chem Lett
; 18(3): 1151-6, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18155906
3.
Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.
Bioorg Med Chem Lett
; 17(20): 5567-72, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17764936
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