Detalles de la búsqueda
1.
Application of the model-informed drug development paradigm to datopotamab deruxtecan dose selection for late-stage development.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 23-28, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37915242
2.
Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.
Mol Pharm
; 10(11): 4207-15, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24066726
3.
Cerebrospinal fluid ß-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses.
Neurodegener Dis
; 12(1): 36-50, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-22922480
4.
Population Pharmacokinetics of Patritumab Deruxtecan in Patients With Solid Tumors.
J Clin Pharmacol
; 63(1): 77-90, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36053771
5.
A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas.
J Clin Oncol
; 41(9): 1714-1724, 2023 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36669146
6.
Cerebrospinal fluid amyloid-ß (Aß) as an effect biomarker for brain Aß lowering verified by quantitative preclinical analyses.
J Pharmacol Exp Ther
; 342(2): 366-75, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22562771
7.
Development of a rapid UPLC-MS/MS method for quantification of saxagliptin in rat plasma and application to pharmacokinetic study.
Biomed Chromatogr
; 26(12): 1482-7, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22334441
8.
Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
J Pharmacol Exp Ther
; 339(3): 922-34, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21930801
9.
Ribociclib Population Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Analysis of Neutrophils in Cancer Patients.
J Clin Pharmacol
; 61(8): 1054-1068, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33713359
10.
Model-Based Meta-Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development.
Clin Pharmacol Ther
; 109(2): 517-527, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32860421
11.
Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.
Clin Pharmacol Ther
; 104(2): 374-383, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29134635
12.
An updated physiologically based pharmacokinetic model for hexachlorobenzene: incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment.
Toxicol Sci
; 91(1): 29-41, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16481338
13.
Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans.
Front Pharmacol
; 5: 274, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25540623
14.
Integrating experimentation and quantitative modeling to enhance discovery of Beta amyloid lowering therapeutics for Alzheimer's disease.
Front Pharmacol
; 3: 177, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23060797
15.
Herb-drug pharmacokinetic interaction between radix astragali and pioglitazone in rats.
J Ethnopharmacol
; 144(2): 300-4, 2012 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23026308
16.
A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.
Bioanalysis
; 4(10): 1205-13, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22651564
17.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22420884
18.
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
J Med Chem
; 54(22): 7772-83, 2011 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21995460
19.
A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling.
Toxicol Sci
; 104(1): 27-39, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18281255
20.
Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane.
Regul Toxicol Pharmacol
; 50(2): 249-60, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18226845