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1.
Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.
Anal Chem
; 94(50): 17388-17395, 2022 12 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36472948
2.
Enhancing Host-Cell Protein Detection in Protein Therapeutics Using HILIC Enrichment and Proteomic Analysis.
Anal Chem
; 92(15): 10327-10335, 2020 08 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32614163
3.
Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies.
Rapid Commun Mass Spectrom
; 33(1): 31-40, 2019 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30286260
4.
Vitamin B12 association with mAbs: Mechanism and potential mitigation strategies.
Biotechnol Bioeng
; 115(4): 900-909, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29205285
5.
Early identification of unusually clustered mutations and root causes in therapeutic antibody development.
Biotechnol Bioeng
; 115(9): 2377-2382, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29777592
6.
Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance.
Pharm Res
; 36(1): 24, 2018 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30536043
7.
Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.
Anal Chem
; 89(23): 12749-12755, 2017 12 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29086552
8.
Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.
Anal Chem
; 88(4): 2041-50, 2016 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26824491
9.
Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities.
Pharm Res
; 33(4): 932-41, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26658915
10.
Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.
J Am Soc Mass Spectrom
; 33(9): 1659-1677, 2022 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36018776
11.
New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study.
J Am Soc Mass Spectrom
; 32(4): 913-928, 2021 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33710905
12.
Structure-Function Assessment and High-Throughput Quantification of Site-Specific Aspartate Isomerization in Monoclonal Antibody Using a Novel Analytical Tool Kit.
J Pharm Sci
; 109(1): 422-428, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31469998
13.
Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process.
MAbs
; 10(3): 500-510, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29336721
14.
Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins.
J Pharm Sci
; 107(10): 2559-2569, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29913140
15.
Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1068-1069: 193-200, 2017 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078145
16.
Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis.
J Pharm Sci
; 106(11): 3222-3229, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28634122
17.
Glycine to glutamic acid misincorporation observed in a recombinant protein expressed by Escherichia coli cells.
Protein Sci
; 21(5): 625-32, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22362707
18.
Characterization and identification of alanine to serine sequence variants in an IgG4 monoclonal antibody produced in mammalian cell lines.
J Chromatogr B Analyt Technol Biomed Life Sci
; 908: 1-8, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23122394
19.
Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping.
J Chromatogr A
; 1218(45): 8140-9, 2011 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21978954
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