Detalles de la búsqueda
1.
Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block ß-amyloid aggregation.
Arch Pharm (Weinheim)
; 357(2): e2300447, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38072670
2.
Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease.
Molecules
; 29(2)2024 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38257233
3.
Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease.
Int J Mol Sci
; 24(3)2023 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36768608
4.
Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease.
Int J Mol Sci
; 23(22)2022 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36430413
5.
Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease.
Molecules
; 27(22)2022 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36431954
6.
Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.
Molecules
; 27(3)2022 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35164325
7.
Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment.
Bioorg Chem
; 112: 104974, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34029971
8.
Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands.
Molecules
; 26(18)2021 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34576998
9.
Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors.
Bioorg Chem
; 94: 103455, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31791680
10.
Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.
Bioorg Chem
; 94: 103387, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31735356
11.
Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry.
Molecules
; 25(6)2020 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192230
12.
Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease.
Molecules
; 25(18)2020 Sep 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32932702
13.
New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.
Molecules
; 25(17)2020 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-32867324
14.
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment.
Molecules
; 25(24)2020 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33322783
15.
Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
Bioorg Med Chem Lett
; 29(23): 126716, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31640885
16.
Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors.
Bioorg Chem
; 91: 103097, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31323527
17.
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
Bioorg Med Chem
; 26(16): 4716-4725, 2018 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30104121
18.
Role of Protein Dimeric Interface in Allosteric Inhibition of N-Acetyl-Aspartate Hydrolysis by Human Aspartoacylase.
J Chem Inf Model
; 57(8): 1999-2008, 2017 08 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28737906
19.
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Bioorg Med Chem
; 25(21): 5981-5994, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28986116
20.
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
Bioorg Med Chem
; 25(15): 3997-4007, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28578994