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1.
Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo.
J Med Chem
; 67(2): 1563-1579, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38206836
2.
A novel anti-LAG-3/TIGIT bispecific antibody exhibits potent anti-tumor efficacy in mouse models as monotherapy or in combination with PD-1 antibody.
Sci Rep
; 14(1): 10661, 2024 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38724599
3.
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Pharmacol Res
; 63(4): 284-93, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21215314
4.
C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 21(15): 4465-70, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737266
5.
Study on Typical Diarylurea Drugs or Derivatives in Cocrystallizing with Strong H-Bond Acceptor DMSO.
ACS Omega
; 6(8): 5532-5547, 2021 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33681594
6.
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem
; 18(12): 4422-32, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20576578
7.
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteers.
Front Pharmacol
; 11: 604314, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33536914
8.
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem Lett
; 19(19): 5632-5, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19700318
9.
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem Lett
; 19(24): 6877-81, 2009 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19896374
10.
Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 57(4): 1236-51, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24456245
11.
Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
ChemMedChem
; 5(6): 827-31, 2010 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-20414917
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