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1.
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
Proc Natl Acad Sci U S A
; 121(7): e2315069121, 2024 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38315851
2.
Metabolism of bifenthrin, ß-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes.
Xenobiotica
; 50(12): 1434-1442, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32672501
3.
Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.
Xenobiotica
; 49(5): 521-527, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29779438
4.
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.
Br J Cancer
; 117(5): e1, 2017 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28324888
5.
Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants.
Drug Metab Dispos
; 45(1): 17-22, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27756789
6.
An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.
Mol Cell Proteomics
; 14(3): 750-60, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25561501
7.
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.
Br J Cancer
; 115(12): 1530-1539, 2016 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27824809
8.
A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor.
J Proteome Res
; 13(2): 866-74, 2014 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24303842
9.
Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.
Drug Metab Dispos
; 42(6): 1022-30, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24671958
10.
Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.
Drug Metab Dispos
; 38(2): 341-6, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19920056
11.
Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.
Toxicology
; 443: 152563, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32805335
12.
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Carcinogenesis
; 30(9): 1571-80, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19608619
13.
Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.
Clin Cancer Res
; 24(9): 2138-2147, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29437786
14.
Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver.
Toxicol Sci
; 158(2): 367-378, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28541575
15.
Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.
Cancer Res
; 75(21): 4573-81, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26363009
16.
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents.
PLoS One
; 9(11): e114055, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25427220
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