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1.
SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines.
Int J Mol Sci
; 21(11)2020 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32486205
2.
Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line.
Int J Mol Sci
; 20(19)2019 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31554327
3.
Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models.
Cancers (Basel)
; 13(21)2021 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34771731
4.
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains.
Int J Antimicrob Agents
; 55(3): 105865, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31866465
5.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
J Med Chem
; 62(5): 2333-2347, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30721061
6.
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
Cancers (Basel)
; 11(6)2019 Jun 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-31248184
7.
Straightforward recursive partitioning model for discarding insoluble compounds in the drug discovery process.
J Med Chem
; 51(10): 2891-7, 2008 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-18419111
8.
Identification of novel nt-MGAM inhibitors for potential treatment of type 2 diabetes: Virtual screening, atom based 3D-QSAR model, docking analysis and ADME study.
Comput Biol Chem
; 72: 122-135, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29274684
9.
Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.
J Med Chem
; 58(24): 9697-711, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26561003
10.
The Chaperoning Activity of Amino-oxyacetic Acid on Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.
ACS Chem Biol
; 10(10): 2227-36, 2015 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26161999
11.
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.
Nat Commun
; 6: 7227, 2015 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26085373
12.
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones.
Curr Top Med Chem
; 4(2): 203-17, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-14754454
13.
Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
J Med Chem
; 46(16): 3555-8, 2003 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12877594
14.
Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.
J Med Chem
; 45(17): 3603-11, 2002 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12166933
15.
3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin.
Farmaco
; 58(9): 659-68, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-13679158
16.
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones.
Farmaco
; 58(5): 357-61, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12729829
17.
Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor.
Eur J Med Chem
; 78: 401-18, 2014 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24704613
18.
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.
J Med Chem
; 55(22): 10277-81, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23083093
19.
A homogeneous HTRF assay for the identification of inhibitors of the TWEAK-Fn14 protein interaction.
J Biomol Screen
; 17(7): 933-45, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22644269
20.
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
J Med Chem
; 55(10): 4806-23, 2012 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468936