Detalles de la búsqueda
1.
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Bioorg Med Chem Lett
; 22(7): 2510-3, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22370270
2.
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Bioorg Med Chem Lett
; 22(5): 1980-4, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22318159
3.
1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 21(18): 5301-4, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21813276
4.
1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 21(18): 5234-8, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21824773
5.
Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.
Brain
; 133(Pt 8): 2475-88, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20627971
6.
Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.
Naunyn Schmiedebergs Arch Pharmacol
; 394(12): 2381-2388, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34550406
7.
Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.
Eur J Pharmacol
; 910: 174452, 2021 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34480885
8.
Glycine and clozapine: potential relevance for the treatment of Parkinson's disease.
Neurodegener Dis Manag
; 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38602420
9.
A comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of anthranilamide derivatives that are multidrug resistance modulators.
J Med Chem
; 49(26): 7646-60, 2006 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-17181148
10.
A medicinal chemistry perspective on structure-based drug design and development.
Methods Mol Biol
; 841: 351-81, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22222460
11.
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with µ-Opioid Agonist Activity.
ACS Med Chem Lett
; 3(3): 227-31, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900459
12.
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
J Med Chem
; 55(7): 3488-501, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22420844
13.
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
J Med Chem
; 55(2): 943-55, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22175766
14.
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Eur J Med Chem
; 55: 94-107, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22840695
15.
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
J Med Chem
; 55(6): 2882-93, 2012 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22335555
16.
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
J Med Chem
; 54(20): 7408-16, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21923116
17.
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
J Med Chem
; 54(15): 5562-75, 2011 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21699209
18.
Synthesis of Functionalized Naphthalenes from Substituted 1-Methoxybenzocyclobutenes.
J Org Chem
; 61(8): 2885-2887, 1996 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-11667129
19.
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 17(9): 2540-4, 2007 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17317165
20.
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
Bioorg Med Chem
; 15(11): 3854-68, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17399990