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1.
SAH derived potent and selective EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(7): 1532-7, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25746813
2.
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Cell Chem Biol
; 30(10): 1191-1210.e20, 2023 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37557181
3.
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol Cancer Ther
; 21(1): 3-15, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34737197
4.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32550998
5.
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
Bioorg Med Chem Lett
; 18(23): 6273-8, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18929486
6.
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Mol Cancer Ther
; 6(3): 945-56, 2007 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17363489
7.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211475
8.
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
Elife
; 62017 11 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-29185984
9.
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.
Structure
; 12(8): 1533-44, 2004 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15296746
10.
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun
; 7: 11384, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27122193
11.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27512831
12.
Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay the Protein Methyltransferase PRMT5.
Assay Drug Dev Technol
; 13(4): 235-40, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26065559
13.
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
J Med Chem
; 46(2): 210-3, 2003 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-12519059
14.
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
J Med Chem
; 47(22): 5467-81, 2004 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15481984
15.
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
J Med Chem
; 45(23): 4961-74, 2002 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-12408707
16.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936698
17.
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure
; 17(12): 1625-1635, 2009 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20004166
18.
A fluorescence polarization assay for screening inhibitors against the ribonuclease H activity of HIV-1 reverse transcriptase.
Anal Biochem
; 351(2): 260-5, 2006 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16527235
19.
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.
Bioorg Med Chem Lett
; 15(11): 2829-33, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911263
20.
Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Bioorg Med Chem Lett
; 14(10): 2433-7, 2004 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15109627
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