Detalles de la búsqueda
1.
Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.
Bioorg Med Chem
; 93: 117462, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37683572
2.
High early phase hemoglobin level is associated with favorable neurological outcome in patients with severe traumatic brain injury.
Am J Emerg Med
; 44: 373-377, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32507479
3.
SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity.
J Pharmacol Exp Ther
; 370(2): 172-181, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31182471
4.
SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.
Diabetes Obes Metab
; 21(10): 2228-2239, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31144422
5.
Mild decrease in heart rate during early phase of targeted temperature management following tachycardia on admission is associated with unfavorable neurological outcomes after severe traumatic brain injury: a post hoc analysis of a multicenter randomized controlled trial.
Crit Care
; 22(1): 352, 2018 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30567590
6.
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 25(15): 4175-4193, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642028
7.
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.
Bioorg Med Chem
; 25(15): 4153-4162, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622905
8.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition.
Bioorg Med Chem
; 24(11): 2486-503, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27112449
9.
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test.
Bioorg Med Chem
; 24(11): 2504-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117261
10.
Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.
Bioorg Med Chem
; 23(15): 4544-4560, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26100443
11.
Effect of physical restraint on glucose tolerance in cynomolgus monkeys.
J Med Primatol
; 42(3): 165-8, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23802316
12.
Temperature difference between jugular bulb and pulmonary artery is associated with neurological outcome in patients with severe traumatic brain injury: A post hoc analysis of a brain hypothermia study.
PLoS One
; 18(5): e0285525, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37155613
13.
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: design and synthesis of benzylpyrazole acylsulfonamides.
Bioorg Med Chem
; 20(2): 714-33, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22209730
14.
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
J Med Chem
; 65(12): 8456-8477, 2022 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35686954
15.
Benefits of Hypothermia for Young Patients with Acute Subdural Hematoma: A Computed Tomography Analysis of the Brain Hypothermia Study.
Neurotrauma Rep
; 3(1): 250-260, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35982984
16.
The earthquake and tsunami--observations by Japanese physicians since the 11 March catastrophe.
Crit Care
; 15(3): 167, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21722338
17.
Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry.
Proteome Sci
; 8: 41, 2010 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-20659346
18.
Urinary trypsin inhibitor suppresses excessive generation of superoxide anion radical, systemic inflammation, oxidative stress, and endothelial injury in endotoxemic rats.
Inflamm Res
; 59(8): 597-606, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20148283
19.
Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase.
J Trauma
; 69(1): 104-9, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20093985
20.
Comparison of the predictability of neurological outcome by serum procalcitonin and glial fibrillary acidic protein in postcardiac-arrest patients.
Neurocrit Care
; 12(2): 252-7, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20033352