Detalles de la búsqueda
1.
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and ß-amyloid inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 88-89: 117333, 2023 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37236021
2.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Molecules
; 28(1)2022 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615435
3.
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Bioorg Chem
; 114: 105129, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34217977
4.
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates.
J Enzyme Inhib Med Chem
; 36(1): 437-449, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33467931
5.
Biphenylalkoxyamine Derivatives-Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity.
Molecules
; 26(12)2021 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34208297
6.
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 35(1): 1944-1952, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33092411
7.
Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity.
Molecules
; 25(11)2020 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32503288
8.
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.
Bioorg Chem
; 90: 103084, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31271942
9.
Novel carbamate derivatives as selective butyrylcholinesterase inhibitors.
Bioorg Chem
; 78: 29-38, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29529519
10.
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.
Molecules
; 23(2)2018 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29414887
11.
Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography.
Electrophoresis
; 38(9-10): 1268-1275, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28169440
12.
Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.
Bioorg Chem
; 72: 315-322, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28501648
13.
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.
Bioorg Med Chem Lett
; 26(16): 4140-5, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27445168
14.
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.
Molecules
; 21(4): 410, 2016 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27023510
15.
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Molecules
; 21(5)2016 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27187348
16.
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Bioorg Med Chem
; 23(7): 1629-37, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25707322
17.
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with ß-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Bioorg Med Chem
; 23(10): 2445-57, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25868744
18.
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem
; 23(17): 5610-8, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26242241
19.
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
Bioorg Med Chem
; 23(9): 2104-11, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813897
20.
Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines.
J Enzyme Inhib Med Chem
; 30(1): 98-106, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24666296