Detalles de la búsqueda
1.
Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA).
Mol Pharmacol
; 78(1): 81-93, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20404073
2.
Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists.
Mol Pharmacol
; 76(3): 618-31, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19542319
3.
Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains.
Mol Pharmacol
; 73(6): 1736-50, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18308898
4.
Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors.
Eur J Pharmacol
; 529(1-3): 95-104, 2006 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-16352303
5.
The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.
Neuropharmacology
; 108: 172-8, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27108932
6.
PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
J Neurosci
; 23(26): 8989-9003, 2003 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14523101
7.
Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTPgammas binding.
J Comp Neurol
; 487(1): 15-27, 2005 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-15861463
8.
Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen.
Psychopharmacology (Berl)
; 232(10): 1831-41, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25420609
9.
Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.
Brain Res Mol Brain Res
; 109(1-2): 168-78, 2002 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-12531526
10.
Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Neuropharmacology
; 86: 259-72, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25107588
11.
Positive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.
CNS Neurosci Ther
; 20(7): 679-84, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24703381
12.
Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats.
Alcohol
; 47(1): 69-73, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23218664
13.
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonists.
J Med Chem
; 55(11): 5061-76, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22574973
14.
Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.
PLoS One
; 7(7): e39131, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22768296
15.
Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 - 2010).
Expert Opin Ther Pat
; 21(5): 637-55, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21417773
16.
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
Curr Top Med Chem
; 11(15): 1902-24, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21470172
17.
The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration.
Drug Alcohol Depend
; 109(1-3): 96-103, 2010 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20089372
18.
Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.
J Med Chem
; 52(22): 7103-12, 2009 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-19817444
19.
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
J Neurochem
; 98(2): 601-15, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16805850
20.
Opposite effects of Zn on the in vitro binding of [3H]LY354740 to recombinant and native metabotropic glutamate 2 and 3 receptors.
J Neurochem
; 94(1): 150-60, 2005 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15953358