Detalles de la búsqueda
1.
A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic Tau mouse model of Alzheimer disease.
Hum Mol Genet
; 31(11): 1788-1805, 2022 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34919689
2.
Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer's disease.
Hum Mol Genet
; 29(1): 49-69, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31595293
3.
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Hum Mol Genet
; 28(2): 177-199, 2019 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30239719
4.
Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Hum Mol Genet
; 27(8): 1332-1342, 2018 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29408999
5.
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Hum Mol Genet
; 27(1): 30-40, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29040533
6.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Hum Mol Genet
; 27(14): 2502-2516, 2018 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29701781
7.
Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.
Hum Mol Genet
; 26(8): 1483-1496, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28186562
8.
Aqua-soluble DDQ reduces the levels of Drp1 and Aß and inhibits abnormal interactions between Aß and Drp1 and protects Alzheimer's disease neurons from Aß- and Drp1-induced mitochondrial and synaptic toxicities.
Hum Mol Genet
; 26(17): 3375-3395, 2017 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28854701
9.
Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Hum Mol Genet
; 25(9): 1739-53, 2016 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26908605
10.
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Hum Mol Genet
; 25(23): 5148-5166, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27677309
11.
Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Hum Mol Genet
; 25(22): 4881-4897, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28173111
12.
Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
Hum Mol Genet
; 24(25): 7308-25, 2015 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26464486
13.
Corrigendum: Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.
Hum Mol Genet
; 28(5): 875-876, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30452626
14.
RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity.
Biochim Biophys Acta
; 1832(12): 2368-78, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24063855
15.
MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
Biochim Biophys Acta
; 1832(12): 2322-31, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24055980
16.
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.
Hum Mol Genet
; 21(11): 2538-47, 2012 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22367970
17.
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.
Hum Mol Genet
; 21(23): 5131-46, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22926141
18.
Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.
Hum Mol Genet
; 26(8): 1597, 2017 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28419260
19.
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Hum Mol Genet
; 21(2): 406-20, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21997870
20.
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid ß production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
Hum Mol Genet
; 21(13): 2973-90, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22492996