Detalles de la búsqueda
1.
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation.
N Engl J Med
; 389(8): 710-721, 2023 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37611121
2.
Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate.
Drug Metab Dispos
; 45(6): 676-685, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28283499
3.
Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay.
Drug Metab Dispos
; 45(6): 604-611, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28325716
4.
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
Drug Metab Dispos
; 45(8): 908-919, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28576766
5.
Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.
J Pharmacol Exp Ther
; 358(3): 397-404, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27317801
6.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
7.
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
Drug Metab Dispos
; 44(3): 320-8, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26714763
8.
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.
Biopharm Drug Dispos
; 36(6): 385-397, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25832562
9.
Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.
Drug Metab Dispos
; 42(3): 369-76, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24335510
10.
Electrophilicity of pyridazine-3-carbonitrile, pyrimidine-2-carbonitrile, and pyridine-carbonitrile derivatives: a chemical model to describe the formation of thiazoline derivatives in human liver microsomes.
Chem Res Toxicol
; 27(12): 2052-61, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25372409
11.
Estimation of the unbound brain concentration of P-glycoprotein substrates or nonsubstrates by a serial cerebrospinal fluid sampling technique in rats.
Mol Pharm
; 11(2): 477-85, 2014 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24380373
12.
Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.
Bioorg Med Chem Lett
; 24(7): 1843-5, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24613378
13.
Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.
Xenobiotica
; 44(12): 1108-16, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24947446
14.
Evaluation of Patient-Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules.
Clin Pharmacol Ther
; 2024 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38671563
15.
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial.
Nat Med
; 30(1): 271-278, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38052910
16.
Practical and economical implementation of online H/D exchange in LC-MS.
Anal Chem
; 85(22): 10904-12, 2013 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24117319
17.
Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.
Drug Metab Dispos
; 41(7): 1425-32, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23633529
18.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Adv Biol (Weinh)
; : e2300131, 2023 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37814378
19.
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Bioorg Med Chem Lett
; 22(9): 3311-6, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22475558
20.
A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: application in mouse pharmacokinetics.
Eur J Drug Metab Pharmacokinet
; 37(1): 23-30, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21948266