Detalles de la búsqueda
1.
Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor.
Mol Pharmacol
; 104(3): 115-131, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37316350
2.
The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor.
Anesth Analg
; 137(3): 691-701, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37058425
3.
Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011-2023.
Molecules
; 29(1)2023 Dec 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38202651
4.
Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.
Molecules
; 28(3)2023 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770942
5.
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers.
J Enzyme Inhib Med Chem
; 35(1): 974-992, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32253945
6.
Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells.
Molecules
; 25(7)2020 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32290281
7.
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR).
Bioorg Med Chem
; 26(1): 50-64, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29162309
8.
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators.
J Enzyme Inhib Med Chem
; 33(1): 303-308, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29280407
9.
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents.
Bioorg Med Chem
; 25(6): 1795-1803, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28238510
10.
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.
Bioorg Med Chem Lett
; 25(8): 1700-1704, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813160
11.
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation.
Biomed Pharmacother
; 177: 116867, 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38889634
12.
Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex.
Neurochem Int
; 178: 105785, 2024 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38838988
13.
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Eur J Pharmacol
; 966: 176329, 2024 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38253116
14.
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Bioorg Med Chem
; 21(2): 456-65, 2013 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23245571
15.
DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms.
ACS Chem Neurosci
; 14(14): 2537-2547, 2023 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37386821
16.
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers.
Eur J Med Chem
; 259: 115716, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37573829
17.
The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers.
Curr Top Med Chem
; 22(31): 2535-2569, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36284399
18.
The piperazine scaffold for novel drug discovery efforts: the evidence to date.
Expert Opin Drug Discov
; 17(9): 969-984, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35848922
19.
Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives.
ChemMedChem
; 17(12): e202200027, 2022 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35416421
20.
New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells.
J Med Chem
; 65(21): 14655-14672, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36269278