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1.
Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment.
PLoS Comput Biol
; 19(10): e1011507, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37792732
2.
Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis.
J Chem Inf Model
; 64(7): 2775-2788, 2024 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37660324
3.
Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies.
Br J Clin Pharmacol
; 89(9): 2691-2702, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37055941
4.
Quantitative assessment of the exposure-efficacy relationship of glucocerebrosidase using Markovian elements in Gaucher patients treated with enzyme replacement therapy.
Br J Clin Pharmacol
; 88(6): 2727-2737, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34957594
5.
Evaluation of ABC gene polymorphisms on the pharmacokinetics and pharmacodynamics of capecitabine in colorectal patients: Implications for dosing recommendations.
Br J Clin Pharmacol
; 87(3): 905-915, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32559325
6.
EMA Review of Daratumumab (Darzalex) for the Treatment of Adult Patients Newly Diagnosed with Multiple Myeloma.
Oncologist
; 25(12): 1067-1074, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33026700
7.
Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule.
Acta Paediatr
; 109(2): 300-308, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31336401
8.
Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts.
J Pharmacol Exp Ther
; 366(1): 96-104, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29691287
9.
Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.
Drug Metab Dispos
; 45(2): 152-159, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27836941
10.
Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.
Br J Clin Pharmacol
; 82(1): 92-107, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26924818
11.
Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.
J Pharmacol Exp Ther
; 354(1): 55-64, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25948593
12.
Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.
Mol Pharm
; 12(9): 3167-74, 2015 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26287948
13.
In vitro-in vivo correlations: general concepts, methodologies and regulatory applications.
Drug Dev Ind Pharm
; 41(12): 1935-47, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26133085
14.
Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.
Mol Pharm
; 11(5): 1403-14, 2014 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-24665996
15.
Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers.
Eur J Pharm Biopharm
; 199: 114293, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38641229
16.
New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model.
Biomed Pharmacother
; 170: 115977, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38056237
17.
Towards precision medicine of long-acting aripiprazole through population pharmacokinetic modelling.
Psychiatry Res
; 333: 115721, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38245977
18.
Innovative in vitro method to predict rate and extent of drug delivery to the brain across the blood-brain barrier.
Mol Pharm
; 10(10): 3822-31, 2013 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23977999
19.
Regulatory Requirements for the Development of Second-Entry Semisolid Topical Products in the European Union.
Pharmaceutics
; 15(2)2023 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36839924
20.
Usage of model combination in computational toxicology.
Toxicol Lett
; 389: 34-44, 2023 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37890682