Detalles de la búsqueda
1.
Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders.
Int J Mol Sci
; 23(15)2022 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955562
2.
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor.
Int J Mol Sci
; 23(16)2022 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36012721
3.
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress.
Int J Mol Sci
; 23(21)2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36362364
4.
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating.
Molecules
; 27(15)2022 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35897934
5.
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.
J Med Chem
; 67(3): 1758-1782, 2024 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38241614
6.
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Bioorg Med Chem Lett
; 23(2): 492-5, 2013 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23237837
7.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.
J Med Chem
; 66(10): 6994-7015, 2023 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37192374
8.
Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
ACS Med Chem Lett
; 13(8): 1329-1336, 2022 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35978701
9.
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.
RSC Med Chem
; 13(7): 873-883, 2022 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35923722
10.
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.
Eur J Med Chem
; 241: 114615, 2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35932568
11.
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.
J Med Chem
; 64(14): 9960-9988, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34251197
12.
Targeting Endocannabinoid Metabolism: an Arrow with Multiple Tips Against Multiple Sclerosis.
ChemMedChem
; 15(21): 1985-2003, 2020 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32762071
13.
Multitarget Therapeutic Strategies for Alzheimer's Disease: Review on Emerging Target Combinations.
Biomed Res Int
; 2020: 5120230, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32714977
14.
Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update.
J Med Chem
; 63(7): 3425-3446, 2020 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31738537
15.
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain.
ChemMedChem
; 13(19): 2090-2103, 2018 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30085402
16.
( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J Med Chem
; 61(5): 2124-2130, 2018 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29451794
17.
Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.
ChemMedChem
; 12(24): 2074-2085, 2017 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29131552
18.
Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases.
Front Neurosci
; 10: 451, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27761108
19.
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies.
Future Med Chem
; 8(13): 1573-87, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27556815
20.
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
J Med Chem
; 59(6): 2612-32, 2016 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26888301