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1.
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.
J Biol Chem
; 297(4): 101177, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34508778
2.
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Arterioscler Thromb Vasc Biol
; 39(10): 1996-2013, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31553664
3.
A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.
Biol Chem
; 399(12): 1363-1374, 2018 11 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30044755
4.
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
J Biol Chem
; 290(30): 18609-20, 2015 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26085104
5.
Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
Proc Natl Acad Sci U S A
; 110(43): 17362-7, 2013 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24101515
6.
PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice.
J Lipid Res
; 56(11): 2133-42, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26323289
7.
Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice.
Circulation
; 125(7): 894-901, 2012 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22261195
8.
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.
Arterioscler Thromb Vasc Biol
; 31(4): 785-91, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21273557
9.
PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1867(12): 159217, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35985474
10.
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.
J Lipid Res
; 52(7): 1383-91, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21518694
11.
In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.
Proc Natl Acad Sci U S A
; 105(15): 5750-5, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18378898
12.
Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.
Hepatology
; 48(2): 646-54, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18666258
13.
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.
Mol Cell Biol
; 26(1): 354-61, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16354705
14.
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
J Clin Invest
; 111(11): 1723-32, 2003 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12782675
15.
Reducing Vascular Calcification by Anti-IL-1ß Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia.
Angiology
; 67(2): 157-67, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25904765
16.
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.
J Biol Chem
; 283(4): 2363-72, 2008 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18039658
17.
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Proc Natl Acad Sci U S A
; 100(3): 928-33, 2003 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12552133
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