Detalles de la búsqueda
1.
Single- and multiple-dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of ASP0367, or bocidelpar sulfate, a novel modulator of peroxisome proliferator-activated receptor delta in healthy adults: Results from a phase 1 study.
Muscle Nerve
; 65(1): 110-120, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34642949
2.
Extending the Specificity of DRL 72-s Behavior for Screening Antidepressant-Like Effects of Glutamatergic Clinically Validated Anxiolytic or Antidepressant Drugs in Rats.
J Pharmacol Exp Ther
; 374(1): 200-210, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32265323
3.
The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs.
J Pharmacol Exp Ther
; 356(3): 534-48, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26699144
4.
Translating Pharmacology into Therapeutics to Fight the Opioid Crisis.
J Pharmacol Exp Ther
; 371(2): 394-395, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31628259
5.
Population pharmacokinetics of the 11ß-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 in healthy volunteers following single and multiple dose regimens.
Biopharm Drug Dispos
; 35(7): 417-29, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25041811
6.
Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease.
Alzheimers Dement
; 10(5 Suppl): S364-73, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24418055
7.
GM-1020: a novel, orally bioavailable NMDA receptor antagonist with rapid and robust antidepressant-like effects at well-tolerated doses in rodents.
Neuropsychopharmacology
; 49(6): 905-914, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38177696
8.
A phase 1b study to investigate the potential interactions between ASP8062 and buprenorphine/naloxone in patients with opioid use disorder.
J Psychopharmacol
; 37(2): 144-154, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36738100
9.
A phase 1 randomized, placebo-controlled study to investigate potential interactions between ASP8062, a positive allosteric modulator of the GABAB receptor, and morphine in recreational opioid users.
J Psychopharmacol
; 37(5): 449-461, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37125424
10.
Activation of adenosine1 receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.
J Pharmacol Exp Ther
; 341(2): 564-70, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22323824
11.
Xanomeline modulation of the blood oxygenation level-dependent signal in awake rats: development of pharmacological magnetic resonance imaging as a translatable pharmacodynamic biomarker for central activity and dose selection.
J Pharmacol Exp Ther
; 341(1): 263-73, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22267203
12.
A phase 1 study to assess potential interaction between ASP8062 and alcohol in healthy adult subjects.
J Psychopharmacol
; 36(6): 756-767, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34994232
13.
Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals.
J Pharmacol Exp Ther
; 336(3): 709-15, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21172908
14.
N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
J Pharmacol Exp Ther
; 336(1): 165-77, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20947638
15.
Cortical influences of serotonin and glutamate on layer V pyramidal neurons.
Prog Brain Res
; 261: 341-378, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33785135
16.
Pharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies.
Clin Pharmacokinet
; 60(1): 79-88, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32533536
17.
A randomized phase 1 single-dose polysomnography study of ASP8062, a GABAB receptor positive allosteric modulator.
Psychopharmacology (Berl)
; 238(3): 867-876, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33433644
18.
Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D1 receptor positive allosteric modulator in patients with schizophrenia.
Neuropsychopharmacology
; 46(6): 1145-1151, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33203954
19.
Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?
Mol Pharmacol
; 77(3): 317-26, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19933774
20.
Single- and Multiple-Dose Safety, Tolerability, and Pharmacokinetic Profiles of ASP8062: Results From 2 Phase 1 Studies.
Clin Pharmacol Drug Dev
; 9(3): 297-306, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31926000