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1.
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.
Eur J Med Chem
; 237: 114410, 2022 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35525212
2.
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.
Cell Rep
; 27(2): 387-399.e7, 2019 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30970244
3.
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.
Eur J Med Chem
; 163: 722-735, 2019 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576903
4.
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells.
Philos Trans R Soc Lond B Biol Sci
; 373(1748)2018 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29685965
5.
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells.
Oncotarget
; 8(40): 68557-68570, 2017 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28978137
6.
The growing structural and functional complexity of the LSD1/KDM1A histone demethylase.
Curr Opin Struct Biol
; 41: 135-144, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27470128
7.
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.
J Med Chem
; 59(4): 1613-33, 2016 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26681404
8.
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv
; 2(9): e1601017, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27626075
9.
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1ß and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
Autoimmunity
; 49(3): 155-165, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26789595
10.
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
J Med Chem
; 59(4): 1501-17, 2016 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26702542
11.
Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents.
ACS Chem Biol
; 10(11): 2589-97, 2015 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26322624
12.
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.
ACS Med Chem Lett
; 6(2): 173-7, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25699146
13.
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Eur J Med Chem
; 94: 163-74, 2015 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25768700
14.
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
J Med Chem
; 57(1): 42-55, 2014 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24325601
15.
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes.
J Med Chem
; 57(12): 5212-25, 2014 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24933420
16.
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.
PLoS One
; 9(5): e96941, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24810902
17.
Correction to 'Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells'.
Philos Trans R Soc Lond B Biol Sci
; 373(1755)2018 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30061471
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