Detalles de la búsqueda
1.
α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution.
Bioorg Chem
; 113: 104955, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34034134
2.
Structure of the human κ-opioid receptor in complex with JDTic.
Nature
; 485(7398): 327-32, 2012 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22437504
3.
Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.
J Org Chem
; 81(21): 10383-10391, 2016 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27462910
4.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Bioorg Med Chem
; 24(16): 3842-8, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27364611
5.
Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.
Mol Pharmacol
; 88(3): 502-11, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26134494
6.
Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs.
Bioorg Med Chem
; 23(17): 5693-701, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26233800
7.
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3- and 4-methyl substituents.
Bioorg Med Chem
; 23(19): 6379-88, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26342544
8.
Isolation of Hemiketal and Hydroxy Ketone Tautomers of Synthetic Intermediates Each Affording 18-Hydroxycortisol-1,6,7-d3.
ACS Omega
; 8(31): 28185-28195, 2023 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37576635
9.
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.
Bioorg Med Chem Lett
; 22(21): 6661-4, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23031594
10.
Designer drugs: a medicinal chemistry perspective (II).
Ann N Y Acad Sci
; 1489(1): 48-77, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32396701
11.
Synthesis and Characterization of the Selective, Reversible PKCß Inhibitor (9 S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9 H,18 H-5,21:12,17-dimethenodibenzo[ e,k]pyrrolo[3,4- h][1,4,13]oxadiazacyclohexadecine-18,20(19 H)-dione, Ruboxistaurin (LY333531).
ACS Chem Neurosci
; 10(1): 246-251, 2019 01 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30156829
12.
Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.
J Med Chem
; 51(12): 3526-39, 2008 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-18512901
13.
Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.
Bioorg Med Chem
; 16(15): 7415-23, 2008 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18602830
14.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic).
J Med Chem
; 61(17): 7525-7545, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30117738
15.
Caged Naloxone: Synthesis, Characterization, and Stability of 3- O-(4,5-Dimethoxy-2-nitrophenyl)carboxymethyl Naloxone (CNV-NLX).
ACS Chem Neurosci
; 9(3): 563-567, 2018 03 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29154536
16.
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic).
J Med Chem
; 61(17): 7546-7559, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30032602
17.
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
J Med Chem
; 50(25): 6383-91, 2007 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-17994682
18.
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
J Med Chem
; 50(14): 3388-91, 2007 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-17569516
19.
Synthesis and Physicochemical Characterization of the One-Carbon Carrier 10-Formyltetrahydrofolate; A Reference Standard for Metabolomics.
Metabolomics
; 13(10)2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29399009
20.
Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues.
ACS Chem Neurosci
; 8(1): 115-127, 2017 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27726337