Detalles de la búsqueda
1.
Discovery of small molecule HIV-1 integrase dimerization inhibitors.
Bioorg Med Chem Lett
; 22(9): 3109-14, 2012 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22483582
2.
New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations.
Int J Biochem Cell Biol
; 41(1): 235-47, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18834955
3.
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 19(13): 3615-8, 2009 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19447621
4.
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.
Bioorg Med Chem Lett
; 18(8): 2530-5, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18381238
5.
Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies.
Eur J Med Chem
; 43(3): 621-32, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-17698257
6.
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.
Int J Biochem Cell Biol
; 39(7-8): 1510-22, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17482499
7.
Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.
J Med Chem
; 50(26): 6580-95, 2007 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18052319
8.
A versatile route to C-6 arylmethyl-functionalized S-DABO and related analogues.
Org Lett
; 9(16): 3157-60, 2007 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-17625879
9.
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
J Med Chem
; 49(20): 6046-56, 2006 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17004718
10.
HIV-reverse transcriptase inhibition: inclusion of ligand-induced fit by cross-docking studies.
J Med Chem
; 48(1): 200-12, 2005 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-15634014
11.
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
J Med Chem
; 48(24): 7789-95, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16302818
12.
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
J Med Chem
; 48(9): 3344-53, 2005 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-15857140
13.
Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity.
J Med Chem
; 48(25): 8000-8, 2005 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16335924
14.
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures.
J Med Chem
; 46(4): 512-24, 2003 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-12570373
15.
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
J Med Chem
; 46(23): 4826-9, 2003 Nov 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-14584932
16.
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
J Med Chem
; 45(9): 1778-84, 2002 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11960489
17.
3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
J Med Chem
; 45(6): 1180-3, 2002 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11881986
18.
Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.
J Med Chem
; 45(8): 1567-76, 2002 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11931611
19.
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
J Med Chem
; 46(12): 2482-93, 2003 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12773052
20.
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
J Med Chem
; 47(5): 1098-109, 2004 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-14971890