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1.
Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 29(4): 659-663, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30638874
2.
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 28(5): 958-962, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439904
3.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28818462
4.
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Bioorg Med Chem Lett
; 26(17): 4165-9, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27496211
5.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576602
6.
Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
J Pharmacol Exp Ther
; 327(3): 620-33, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18772321
7.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234467
8.
Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.
ACS Med Chem Lett
; 7(12): 1082-1086, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994742
9.
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.
ACS Med Chem Lett
; 7(3): 289-93, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985317
10.
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.
J Med Chem
; 59(24): 11171-11181, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27958732
11.
Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(4): 2213, 2019 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30734560
12.
Evaluation and optimization of compound solubilization and delivery methods in a two-tiered ion channel lead optimization triage.
Assay Drug Dev Technol
; 10(2): 202-11, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22085018
13.
Design of an automated enhanced-throughput platform for functional characterization of positive allosteric modulator-induced leftward shifts in apparent agonist potency in vitro.
J Lab Autom
; 17(2): 104-15, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22357567
14.
The P2X3 antagonist P1, P5-di[inosine-5'] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons.
J Pharmacol Exp Ther
; 315(1): 405-13, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16014755
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