Detalles de la búsqueda
1.
Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells.
J Pharmacol Exp Ther
; 388(1): 201-208, 2024 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37977812
2.
Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats).
Drug Metab Dispos
; 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38388380
3.
Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.
Mol Pharm
; 20(6): 3020-3032, 2023 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37134201
4.
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.
Pharm Res
; 40(11): 2639-2651, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37561322
5.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779864
6.
A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.
Anal Chem
; 92(14): 9745-9754, 2020 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551505
7.
In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach.
Drug Metab Dispos
; 49(6): 470-478, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33824168
8.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975793
9.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30135178
10.
Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.
J Pharmacol Exp Ther
; 364(3): 390-398, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29326367
11.
Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies.
Drug Metab Dispos
; 46(11): 1703-1711, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30171163
12.
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.
Mol Pharm
; 15(3): 1284-1295, 2018 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29433307
13.
In vitro studies with two human organic anion transporters: OAT2 and OAT7.
Xenobiotica
; 48(10): 1037-1049, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28945155
14.
Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach.
Drug Metab Dispos
; 45(4): 409-417, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28179375
15.
Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites.
Drug Metab Dispos
; 45(7): 737-747, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28438781
16.
Evaluation of the Impact of Ritlecitinib on Organic Cation Transporters Using Sumatriptan and Biomarkers as Probes.
J Clin Pharmacol
; 63(7): 784-797, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36807251
17.
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment.
J Med Chem
; 65(21): 14578-14588, 2022 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36270005
18.
Development and implementation of urinary transporter biomarkers to facilitate assessment of drug-drug interaction.
Bioanalysis
; 14(14): 971-984, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-36066071
19.
Evaluation of the Effect of Abrocitinib on Drug Transporters by Integrated Use of Probe Drugs and Endogenous Biomarkers.
Clin Pharmacol Ther
; 112(3): 665-675, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35344588
20.
Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides.
J Biol Chem
; 285(18): 13498-506, 2010 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-20167598