Detalles de la búsqueda
1.
Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model.
Biopharm Drug Dispos
; 41(7): 283-294, 2020 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-32562504
2.
Reduction of Kiss1 expression in the anteroventral periventricular nucleus is associated with atrazine-induced attenuation of the luteinizing hormone surge in female rats.
Biol Reprod
; 100(1): 41-48, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30010721
3.
A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.
Bioorg Med Chem Lett
; 29(4): 654-658, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30598349
4.
An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats.
J Reprod Dev
; 63(3): 305-310, 2017 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-28344194
5.
Effects and therapeutic potentials of kisspeptin analogs: regulation of the hypothalamic-pituitary-gonadal axis.
Neuroendocrinology
; 99(1): 49-60, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24356680
6.
The effects of chronic subcutaneous administration of an investigational kisspeptin analog, TAK-683, on gonadotropin-releasing hormone pulse generator activity in goats.
Neuroendocrinology
; 100(2-3): 250-64, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25428554
7.
Reduced responsiveness of kisspeptin neurons to estrogenic positive feedback associated with age-related disappearance of LH surge in middle-age female rats.
Gen Comp Endocrinol
; 193: 121-9, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23851104
8.
Differential effects of continuous exposure to the investigational metastin/kisspeptin analog TAK-683 on pulsatile and surge mode secretion of luteinizing hormone in ovariectomized goats.
J Reprod Dev
; 59(6): 563-8, 2013 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24047956
9.
Target 2035 - an update on private sector contributions.
RSC Med Chem
; 14(6): 1002-1011, 2023 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37360399
10.
Target 2035 - update on the quest for a probe for every protein.
RSC Med Chem
; 13(1): 13-21, 2022 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35211674
11.
Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats.
Biol Reprod
; 81(6): 1216-25, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19684332
12.
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one-month depots of TAK-448 and TAK-683, investigational kisspeptin analogs, in male rats and an androgen-dependent prostate cancer model.
Eur J Pharmacol
; 822: 138-146, 2018 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29355559
13.
Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model.
Eur J Pharmacol
; 828: 126-134, 2018 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29580912
14.
Donated chemical probes for open science.
Elife
; 72018 04 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29676732
15.
Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition.
Springerplus
; 5(1): 1429, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27652005
16.
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.
J Med Chem
; 59(19): 8804-8811, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27589480
17.
Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats.
Endocrinology
; 146(10): 4431-6, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-15976058
18.
Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats.
Anim Reprod Sci
; 159: 87-93, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26051610
19.
Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies.
J Clin Endocrinol Metab
; 99(8): E1445-53, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24762108
20.
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
J Med Chem
; 57(14): 6105-15, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24918545