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1.
8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.
Bioorg Med Chem Lett
; 25(7): 1431-5, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754491
2.
Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.
Bioorg Med Chem Lett
; 24(22): 5175-80, 2014 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25442307
3.
The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.
Bioorg Med Chem Lett
; 24(23): 5460-5, 2014 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25455484
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