Detalles de la búsqueda
1.
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
J Pharmacol Exp Ther
; 384(1): 197-204, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36273821
2.
A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.
Bioorg Med Chem Lett
; 29(4): 654-658, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30598349
3.
A quantitative LC/MSMS method for determination of edoxaban, a Xa inhibitor and its pharmacokinetic application in patients after total knee arthroplasty.
Biomed Chromatogr
; 32(6): e4213, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29451685
4.
Identification of AHCY inhibitors using novel high-throughput mass spectrometry.
Biochem Biophys Res Commun
; 491(1): 1-7, 2017 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533090
5.
Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.
Biochem Biophys Res Commun
; 482(2): 195-201, 2017 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27836545
6.
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem Biophys Res Commun
; 486(3): 626-631, 2017 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28315326
7.
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
Bioorg Med Chem
; 25(21): 5995-6006, 2017 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28988629
8.
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg Med Chem Lett
; 23(12): 3662-6, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23664874
9.
Quantitation and characterization of glucosylsphingosine in cerebrospinal fluid (CSF), plasma, and brain of monkey model with Gaucher disease.
Drug Metab Pharmacokinet
; 53: 100530, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37924723
10.
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.
Bioorg Med Chem Lett
; 22(20): 6391-6, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22975302
11.
Highly-sensitive simultaneous quantitation of glucosylsphingosine and galactosylsphingosine in human cerebrospinal fluid by liquid chromatography/tandem mass spectrometry.
J Pharm Biomed Anal
; 217: 114852, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636011
12.
Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys.
Drug Metab Pharmacokinet
; 36: 100359, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33348238
13.
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration.
Drug Metab Pharmacokinet
; 41: 100408, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34710650
14.
Pt3Ti nanoparticles: fine dispersion on SiO2 supports, enhanced catalytic CO oxidation, and chemical stability at elevated temperatures.
Langmuir
; 26(13): 11446-51, 2010 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-20586414
15.
2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.
Bioorg Med Chem
; 18(14): 5157-71, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20580563
16.
Quantitative application of flow cytometry for the analysis of circulating human T cells: A preclinical pharmacokinetic study.
Drug Metab Pharmacokinet
; 35(2): 207-213, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-31980378
17.
Development of a bioanalytical method for circulating human T cells in animals using Arthrobacter luteus-based quantitative polymerase chain reaction and its application in preclinical biodistribution studies.
Regen Ther
; 15: 251-257, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33426226
18.
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells.
Sci Rep
; 10(1): 17884, 2020 10 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33087808
19.
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).
Bioorg Med Chem
; 16(8): 4715-32, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313304
20.
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).
Bioorg Med Chem
; 16(8): 4699-714, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313930